Stage IIB의 자궁경부 침윤성 편평상피 암종으로 방사선 치료를 받은 환자의 예후와 p53단백과 Bax발현과의 상관관계

초록

Background: The objetive was to evaluate the immunohistochemical expression of p53 and bax proteins as prognostic markers in FIGO stage IIb invasive squamous cell carcinoma of the uterine cervix. Method: Sixty-five cases of squamous cell carcinoma of cervix (stage IIB) diagnosed between October 1996 and December 2003 were analyzed retrospectively for bax and p53 expression deteremined immunohistochemically and were correlated tot he patients' overall survival and disease-free survival. Reult: The overall 5-year survival (OS) and disease-free survival (DFS) were 65.1% and 62.9%. p53 and bax immunoreactivity was seen in 26.2% and 52.3% of cases with variable levels of expression, respectively. In unirariate analysis, only p53 positiviey correlated with poor survival in DFS but not in multivariated analysis by Cox's regression. conclusion: Neither p53 nor bax expression are independent predictors of prognosis in stage IIb cervical squamous cell cancers. Evaluation of co-expression of them may affet clinical outcome and needs further investigation.