Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites

Belgodere, Jorge A.; Son, Dongwan; Jeon, Bokyoung; Choe, Jongwon; Guidry, Anna C.; Bao, Adam X.; Zamin, Syed A.; Parikh, Umang M.; Balaji, Swathi; Kim, Myungwoong; Jung, Jangwook P.

doi:10.1021/acsbiomaterials.1c00427

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Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites

Belgodere, Jorge A.;
Son, Dongwan;
Jeon, Bokyoung;
Choe, Jongwon;
Guidry, Anna C.;
... Kim, Myungwoong;
외 5명

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초록

We report the use of phenolic functional groups of lignosulfonate to impart antioxidant properties and the cell binding domains of gelatin to enhance cell adhesion for poly(ethylene glycol) (PEG)-based scaffolds. Chemoselective thiol-ene chemistry was utilized to form composites with thiolated lignosulfonate (TLS) and methacrylated fish gelatin (fGelMA). Antioxidant properties of TLS were not altered after thiolation and the levels of antioxidation were comparable to those of L-ascorbic acid. PEG-fGelMA-TLS composites significantly reduced the difference in COL1A1, ACTA2, TGFB1, and HIF1A genes between highscarring and low-scarring hdFBs, providing the potential utility of TLS to attenuate fibrotic responses.

키워드

antioxidation; fish gelatin; lignosulfonate; fibrosis; wound healing; MECHANICAL-PROPERTIES; FISH GELATIN; ANTIOXIDANT; HYDROGELS; BIOLOGY; HEALTH; GROWTH

제목: Attenuating Fibrotic Markers of Patient-Derived Dermal Fibroblasts by Thiolated Lignin Composites

저자: Belgodere, Jorge A.; Son, Dongwan; Jeon, Bokyoung; Choe, Jongwon; Guidry, Anna C.; Bao, Adam X.; Zamin, Syed A.; Parikh, Umang M.; Balaji, Swathi; Kim, Myungwoong; Jung, Jangwook P.

DOI: 10.1021/acsbiomaterials.1c00427

발행일: 2021-06-14

유형: Article

저널명: ACS Biomaterial Science and Engineering

권: 7

호: 6

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