Ground silica monolith particles prepared by a new simplified and cost-effective process

초록

We have been studying silica monolith particles for raw material of chromatographic stationary phases. In this study, the manufacturing process for silica monolith particles becomes much simpler by removing the sieving and washing steps in comparison with the previous methods, causing great reduction of production cost. In addition, silica monolith particles with reduced average particle size and increased average pore size are obtained in this method. Thus the stationary phases comprising the silica monolith particles of this study result in high separation performance in liquid chromatography. The manufacturing process of silica monolithic particles of this study includes three steps: the step for formation of bulk monolith (step 1), the step for powdering the silica monolith (step 2), and the step for calcination of the powdered silica monolith (step 3). The average particle sizes and pore sizes were affected by variation of reaction conditions such as formulation of reaction mixture, combination of heating steps, and, process temperature, etc.