Organic Biomass Mediated-Cerium Oxide Nanoparticles for Multifunctional Activity: Anticancer MCF-7 Breast Cancer Cells, Antibacterial, Antioxidant, and Dye Degradation

초록

This study presents the green synthesis of cerium oxide nanoparticles (CeO2 NPs) using Albizia julibrissin flower extract, offering an eco-friendly and cost-effective approach to nanoparticle fabrication. The synthesized CeO2 NPs were characterized using UV-vis spectroscopy, which revealed a characteristic absorption peak at 310 nm, XRD confirming a cubic fluorite structure with an average crystallite size of 30 nm, and SEM/TEM showing a spherical morphology with particle sizes ranging from 10-25 nm. The nanoparticles exhibited potent antibacterial activity, with inhibition zones of 17.6 +/- 0.8 mm against Escherichia coli and 15.2 +/- 0.6 mm against Staphylococcus aureus, demonstrating their broad-spectrum antimicrobial efficacy. The antioxidant potential, evaluated via DPPH assay, showed a radical scavenging activity of 78.4% at 100 mu g/mL, comparable to standard antioxidants. The cytotoxicity study on MCF-7 breast cancer cells revealed an IC50 value of 48.6 mu g/mL, indicating significant anticancer activity. Furthermore, the photocatalytic degradation of methylene blue dye under visible light illumination achieved a 92.3% degradation efficiency within 120 min, highlighting the environmental remediation potential of CeO2 NPs. These findings establish plant-mediated CeO2 NPs as promising candidates for biomedical and environmental applications.

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