St14 expressio analysis for the prognosis and management of ER negative breast cancer

초록

to elucidate the roles of a type II transmembrane serine protease St14/Prss14, during breast cancert progression, we utiliesed pubpica;;y accessible databases including TCGA, GEO, NCI-60. and CCLE. Survivial of breast cancer patients with high ST14/Prss14 expression is significantly poor in estrogen (ER) negative populations regarless of the ratios of ST14/Prss14 to tits inhibbitors, SPINT1 or SPINT2.