Invasive aspergillosis complicated by occlusion of internal carotid artery and cerebral infarction

초록

background & Significance : Invasive aspergillosis is one of rare causes of mortality for the immunecompromised patients. Fungal infection sometimes involved internal carotid artery, resulting in cerebral infarction. Case : We present a case of invasive aspergillosis complicated by the occlusion of the internal carotid artery and cerebral infarction in a patient with diabetes mellitus. Although initial biopsy did not find the pathogen, the repeated attempts of sampling showed aspergillosis. Combination of surgical removal of necrotic tissue and voriconazole medication improved symptoms and reduced the burden of infection. Conclusions or Comments : Invasive aspergillosis should be considered for rare cause of carotid artery occlusion. If fungal infection is suspected, repeated sampling might increase the chance for the identifying the pathogen, in spite of failure of initial biopsy. Combination of voriconazole medication and surgery could be treatment option for invasive aspergillosis .