The effect of a few genetic polymorphism on childhood asthma

초록

We enrolled 30 childhood asthma patients and 30 controls. We evaluated genetic polymorphism of GSTM1 and GSTT1, and urinary 1-OH-pyrene as the marker of exposure to PAHs. Polymorphism of GSTM1 is related strongly with 1-OH-pyrene. The risk of asthma was frequent 3.5 times more than control groups in the group of wild GSTM1 genotype and high 1-OH-pyrene levels comparing to those with wild GSTM1 genoetype and low 1-OH pyrene levels. It increased to 4.5 times with null GSTM1 genotype and low 1-OH-pyrene levels. However, it was 9 times more with both null GSTM1 and high level of 1-OH-pyrene. The risk of ashtma can be increased with exposure to PAHs and genetic polymorphism related to the metabolism of them.