Prognostic Impact of Combined Dysglycemia and Hypoxic Liver Injury (HLI) at Admission in Patients with ST-Elevation Myocardial Infarction (STEMI) Undergone Primary Percutaneous Coronary Intervention (PCI) : Data from INTERSTELLAR cohort

초록

Objectives Dysglycemia at admission is known to predict the prognosis of ST-elevation myocardial infarction (STEMI). Recently, hypoxic liver injury (HLI) at admission has been proposed as a novel prognostic marker for STEMI. Therefore, we sought to evaluate the prognostic impact ofcombined dysglycemia and HLI at admission in patients with STEMI undergoneprimary PCI. Methods From 2007 to 2014, a total of 1497consecutive patients (79.3% male, mean age 60.5±13.1 years) who underwentprimary PCI for STEMI were analyzed retrospectively.Dysglycemia was defined as either hypoglycemia (serum glucose <90 mg/dl) or hyperglycemia (serum glucose ≥200 mg/dl). HLI was defined as ≥2-fold increase of any serum aminotransferase above upper normal limit. Results Of the 1497 patients, there were 19 (1.3%) patients in group 1, 882 (58.9%) patients in group 2, 278 (18.6%) patients in group 3, 7 (0.5%) patients in group 4, 215 (14.4%) patients in group 5, and 96 (6.4%) patients in group 6.Over a mean follow-up period of 2.1±1.5 years, there were 85 (5.7%) in-hospital mortality and 121 (8.1%) all-cause mortality. Conclusions Combined dysglycemia and HLI at admission is associated with early mortalityin patients with STEMI underwent primary PCI. Hypoglycemia at admission is associated with mid-term STEMI mortality