Efficient chronological lifespan extension in yeast by intermittent calorie restriction

초록

Calorie restriction (CR) has been known to extend life span of many species. In yeast, CR extends both replicative life span and chronological life span. On the other hand, feasting has been also known to provide beneficial effects as CR. In order to verify the effect of feasting, we cultured yeast under intermittent feasting (IF) conditions and compared chronological life span of IF yeast to that of normal and CR control groups. As the results, we observed that IF efficiently prolonged yeast chronological life span. Further molecular analysis revealed that IF induces life span extension by similar mechanism as CR. We also found that IF-induced yeast chronological life span extension is TOR1-independent.