Multicomponent-Loaded Vesosomal Drug Carrier for Controlled and Sustained Compound Release

초록

Liposomeshave been extensively adopted in drug delivery systemswith clinically approved formulations. However, hurdles remain interms of loading multiple components and precisely controlling theirrelease. Herein, we report a vesosomal carrier composed of liposomesencapsulated inside the core of another liposome for the controlledand sustained release of multiple contents. The inner liposomes aremade of lipids with different compositions and are co-encapsulatedwith a photosensitizer. Upon induction of reactive oxygen species(ROS), the contents of the liposomes are released, with each typeof liposome displaying distinct kinetics due to the variance in lipidperoxidation for differential structural deformation. In vitro experimentsdemonstrated immediate content release from ROS-vulnerable liposomes,followed by sustained release from ROS-nonvulnerable liposomes. Moreover,the release trigger was validated at the organismal level using Caenorhabditis elegans. This study demonstrates apromising platform for more precisely controlling the release of multiplecomponents.

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