A novel cellular micro-biomechanics tool for screening and detecting biomechanical characteristics of breast cancer

초록

A novel cellular micro-biomechanics tool for screening and detecting biomechanical characteristics of breast cancer Soonjo Kwon Improving our fundamental understanding of breast tissue biomechanics and their relationship to tumorigenesis and tumor progression is critical for the continued development of new and more effective treatments for breast cancer. New insights from this field will be useful for clinical applications. We are developing a new technology to research the micro-biomechanics of breast cancer more fully. New insights from this field will have clinical applications. The device will apply mechanical forces to cultured breast tissues that will mimic the pattern observed in breast cancer tumorigenesis. The device thus reproduce key structural, functional, and biomechanical properties of breast tissues with greater fidelity to in vivo tissues than current laboratory methods. Information gathered provide a bridge to clinical diagnosis and treatment. This low-cost, high-throughput technology provide alternatives to animal and clinical studies in medical research and new tools for the individualized treatment of breast cancer. This also provide valuable multidisciplinary education and research opportunities in newly developing fields. 1.　biomechanical microenvironment 2.　tumorigenesis 3.　3D engineered tissue 4.　dynamic culture device