Chondrogenesis of Periosteum-derived Progenitor Cells on Hyaluronic Acid Fiber Scaffold (Hyalograft？ 3D)

초록

Periosteum-derived progenitor cells (PDPCs) were isolated and characterized by flow cytometric analysis using fluorescence-activated cell sorter (FACS). The chondrogenesis of PDPCs was performed on hyaluronic acid fibers (Hyalrograft？ 3D) in chondrogenic induction medium. PDPCs showed the chondrogenic potential when cultured on hyaluronic acid fibers. These results showed that the characterized PDPCs were the chondrogenic progenitor cells and Hyalrograft？ 3D served as a useful carrier for PDPCs in transplantation, proliferation, matrix synthesis and differentiation. Therefore, it could be used as a matrix for healing the defected cartilage.