Effects of fermented milk supplemented with pumpkin(Cucurbita moschata) on serum lipids in postmenopausal osteoporosis model rats

초록

In order to investigate the effects of fermented milk supplement containing pumpkin on serum lipid profiles in postmenopausal osteoporosis model rats. Twenty three female Sprague-Dawley rats weighing 200g were ovariectomized and then were randomly assigned to three groups (low calcium diet; LCD, standard diet of basic AIN-76; control, standard diet + fermented milk supplement containing pumpkin; case group) and each were fed a low calcium diet for three weeks. After three weeks, LCD group was sacrificed and the rest group was fed an experimental diet for 4 weeks. Triglyceride and LDL-cholesterol level in serum were significantly lower in the case group compared to the LCD and control group. Total cholesterol level and the ratio of LDL-cholesterol to HDL-cholesterol in serum were significantly lower in case group compared to the LCD group. Serum HDL-cholesterol level and the ratio of HDL-cholesterol to total cholesterol were significantly higher in case group compared to the rest groups. Serum total cholesterol level was positively correlated with LDL-cholesterol level but negatively correlated with the ratio HDL-cholesterol to total cholesterol. Serum HDL-cholesterol level was positively correlated with the ratio HDL-cholesterol to total cholesterol but negatively correlated with the ratios LDL-cholesterol to HDL-cholesterol. Serum LDL-cholesterol level was negatively correlated with the ratio HDL-cholesterol to total cholesterol but positively correlated with the ratio LDL-cholesterol to HDL-cholesterol. These findings suggest a possible anti-hyperlipidemic effect of fermented milk supplement containing pumpkin in postmenopausal osteoporosis model rats.