Dog Kinome: A comparative study with human, mouse and rat kinomes

초록

Protein phosphorylation is one of the most important phenomenon which play crucial roles in regulation, activation and translocation of most of the proteins. Protein kinases are responsible for protein phospphorylation typically in serine, theronine and tyrosine residues of a protein. Owing to this function, protein kinases are by far the most extensively studied proteins in biochemistry, molecular biology, bioinformatics and proteomics. Here, we identified, classified and analysed protein kinases found in dog genome and compared the dog kinome with that of human, mouse, rat. We found that at least nine kinases are dog-specific which are absent in human, mouse and rat.