Imparied NO release by phosphorylation of neuronal nitric oxide synthase in interactions between trophoblast and cytokines generating preeclampsia

초록

The present study is to identify the possible & causative mechanisms of preeclampsia (PE), which is based on modulations in constitutive nitric oxide (NO) synthesis (particularly by neuronal NOS in trophoblast) modulated by the cytokine mediators produced by inflammatory reactions. Impairment of the endothelial NO production in pregnancy has been suggested as a major cause of the incidence of PE, which is associated with maternal hypertension in pregnancy, proteinuria, edema, fetal growth restriction and premature birth, and also with increases of placental inflammatory cytokines. However, NO is also synthesized by peripheral non-adrenergic non-cholinergic (NANC) nerves in the vessels, thereby mediating vascular tone.