Alteration of hepatitis B serostatus among allogeneic blood stem cell transplant recipients at Inha University Hospital

초록

Post transplant serology of the recipient was unavailable in 41 cases (death, omission of the test, or lost to follow up) and data of 72 pairs were available. There were no HBV carriers among donors; 23 were seronegative and 48 had antibody against HBV. There were six HBV carriers among recipients; 20 were seronegative and 46 seropositive for HBV antibody. Two HBV carriers among recipients showed seroconversion with loss of HBsAg and gain of HBsAb, one from seronegative donor and the other from HBsAb positive donor. One HBV carrier lost HBsAg without seroconversion after receiving alloBSCT from seropositive donor. Three HBV carrier remained persistent carrier after receiving alloBSCT from two seropositive and one seonegative donors. Twelve seronegative recipient gained HBsAb, 8 from HBsAb positive donors and 4 from seronegative donors. Seven seropositive patients lost HBsAb, 3 recipients from HBsAb positive donors and 4 from HBsAb negative donors. Reverse seroconversion occurred in one patient who was transplanted from HBsAb positive donor.