Effects of red ginseng dietary fiber on promoting probiotic properties of Lactiplantibacillus plantarum

초록

Red ginseng dietary fiber (RGDF) is a residue of the processed ginseng product but still contain bioactive constituents that can be applied as prebiotics. In this study, we evaluated changes on growth and pH profiles and probiotic properties of strains that belong to family Lactobacillaceae with RGDF supplementation. RGDF supplementation promoted SCFA production, carbon source utilization, and gut epithelial adhesion of L. plantarum and inhibited attachment of enteropathogens. Intracellular and extracellular metabolome analyses were conducted to understand specific mechanisms on the metabolic alteration by RGDF and to discover novel bioactive compounds secreted by the RGDF-supplemented probiotic strain. RGDF induced metabolic alteration, especially associated with central carbon metabolism, and produced RGDF-specific metabolites secreted by L. plantarum, respectively. RGDF supplementation had distinct effects on L. plantarum metabolism compared with fructooligosaccharide supplementation These findings present potential applications of RGDF as prebiotics and bioactive compounds produced by RGDF-supplemented L. plantarum as novel postbiotic metabolites for human disease prevention and treatment.