HIV 모델에서 치료에 관한 최적 제어와 STI 제어

초록

We formulate a dynamic mathematical model that describes the interaction of the immune system with the human immunodeficiency virus(HIV) and that permits drug "cocktail" therapies. We derive HIV therapeutic strategies by formulating and analyzing an optimal control problem using two types of dynamic treatments representing reverse transcriptase inhibitors(RTIs) and protease inhibitors(PIs). In addition, we formulate and derive suboptimal structured treatment interruptions(STI) in antiviral therapy that include drug-free periods of immune-mediated control of HIV.