INDUCTION MECHANISMS FOR L - LTP AT THALAMIC INPUT SYNAPSES TO THE LATERAL AMYGDALA: INVOLVEMENT OF mGluR5

초록

Cell surface receptors and channels involved in the regulation of intracellular calcium play a major role in the induction phase of synaptic plasticity. While L-LTP at thalamo-amygdala synapses is thought to be critical for auditory fear conditioning, it has not been clear what kinds of such receptors and channels are involved in the induction of amygdala L-LTP. Here we have examined the effect of antagonists for NMDA receptors, L-type calcium channels and group I metabotropic glutamate receptors on L-LTP induction. The NMDA receptor antagonist D-AP5 (50 M) completely prevented induction of L-LTP.