Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.

Bae, Munhyung; An, Joon Soo; Bae, Eun Seo; Oh, Jedo; Park, So Hyun; Lim, Yeonjung; Ban, Yeon Hee; Kwon, Yun; Cho, Jang-Cheon; Yoon, Yeo Joon; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan

doi:10.1021/acs.orglett.9b01057

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Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.

Bae, Munhyung;
An, Joon Soo;
Bae, Eun Seo;
Oh, Jedo;
Park, So Hyun;
... Cho, Jang-Cheon;
외 7명

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초록

The chemical analysis of a Streptomyces strain, from a Korean volcanic island, discovered new benz[a]anthracene dimers linked by a thioether bond. The structures of donghaesulfins A and B (1 and 2) were elucidated by spectroscopic analysis including energy-dispersive X-ray. Their configurations were determined by ROESY NMR data, DP4 calculations, the modified Mosher's method, and ECD calculations. Donghaesulfins A (1) induced quinone reductase, whereas donghaesulfin B (2) displayed antiangiogenesis activity.

키워드

SULFUR; OHMYUNGSAMYCINS; ANTIBIOTICS

제목: Donghaesulfins A and B, Dimeric Benz[a]anthracene Thioethers from Volcanic Island Derived Streptomyces sp.

저자: Bae, Munhyung; An, Joon Soo; Bae, Eun Seo; Oh, Jedo; Park, So Hyun; Lim, Yeonjung; Ban, Yeon Hee; Kwon, Yun; Cho, Jang-Cheon; Yoon, Yeo Joon; Lee, Sang Kook; Shin, Jongheon; Oh, Dong-Chan

DOI: 10.1021/acs.orglett.9b01057

발행일: 2019-05-17

유형: Article

저널명: Organic Letters

권: 21

호: 10

페이지: 3635 ~ 3639