Factors associated with Spine fractures in Parkinson’s disease

초록

Objective <br> Parkinson’s disease (PD) and osteoporosis are two conditions affecting a substantial portion of the elderly population. Furthermore, osteoporosis and osteopenia are very common findings in patients with PD. Osteoporosis is a pathology with multi-factorial etiopathogenesis which becomes fragile and more exposed to the risk of fractures. The risk of fall-related fracture is also five-fold higher in patients with PD than in age- and sex-matched controls. <br> A better understanding of the associated factors with fracture would be needed to prevent or treat PD patients who will require treatment. So, we want to study the patient with/without fall; 1. Different characteristics of patients, 2. Type, location of spine fracture and the degree of bone loss according to the fall, 3. Relation between the types of vertebral fracture and the degree of bone loss, the body mass index. Therefore, the aim of this study was to analyze the characteristics of vertebral fractures in elderly patients with PD. <br> <br>Subjects and Methods <br> This study was conducted in a single institution where they receive 311 inpatients. Data on patients with PD was collected from Jan, 2002 to Jan, 2017 at a single institution. The data used KCD-6 (Korean Standard Classification of Diseases) for its diagnostic code and it was obtained using G20 for PD. We excluded those individuals who were diagnosed with secondary PD (except previous stroke) and previous history of fracture before diagnosed with PD. <br> <br>Results <br> The patient demographics are summarized in Table 1. The differences between faller/non-fallers are not significant in age, age of onset of PD, duration of PD, sex ratio, pharmacologic treatment and body mass index. Characteristics of vertebral fracture (type, location) and the degree of bone loss according to the fall summarized in Table 2. The rate of osteoporosis in BMD was higher than that of osteopenia in patients with T-L spine fracture regardless of fall. The