중년 남성의 근 체력 및 염증 수준과 백혈구 텔로미어 길이와의 관련성

초록

This study was to investigate the effects of muscular fitness and inflammation level on telomere length in middle aged men. This study was conducted on 106 middle aged men. We examined muscle fitness, such as muscle mass, grip strength and maximal knee eccentric isometric strength (MKEIS), inflammation level including c-reactive protein (CRP) and lactate dehydrogenase (LDH), and telomere length. LDH level has shown a negative correlation with telomere length (r=-.289, p<.01). When adjusted for age and muscle fitness related factors, as LDH level increased by 1 UI/L, the telomere length (T/S ratio) decreased by 0.0013 (p<.01). When adjusted for age and obesity related factor such as BMI, percent of body fat, and waist circumference, as LDH level increased by 1 UI/L, telomere length (T/S ratio) decreased by 0.0014(p<.01). When adjusted for all variable, as LDH level increased by 1 UI/L, telomere length (T/S ratio) decreased by 0.0012 (p<.01). Overall, LDH as muscle damage marker influenced telomere length in middle-aged men.

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