Crystallization of Acetaminophen Nano-particle using Supercritical Fluids

초록

To prepare fine particle of acetaminophen, the experiments have been conducted at various temperatures, pressures, solvents, solution concentrations and solution feed volumes by Aerosol Solvent Extraction System (ASES). In each case, the experiments investigated the particle sizes and morphologies that were analyzed by Scanning Electron Microscopy (SEM) and Laser Diffraction Particle Size Analyzer (PSA, Otsuka electronics ELS 8000). FT IR (Bruker IFS 120 spectrometer) also analyzed the chemical composition. The result shows that particle size has been measured to be 3~4 um, which was 1/40 of pure acetaminophen. The irregular and acicular morphology has been changed to be regular, and the broad particle size distribution range has been changed from 193.4 um to 8.27 um.