Sexually dimorphic micturition and the changes after intravesical PGE2 instillation in awake rats

초록

Introduction: To obtain information on the different mechanisms between awake male and female rats’ micturition, using an overactive model with intravesical PGE2 instillation. Materials and Methods: Sprague Dawley rats (6 male, 6 female) were used. A catheter was intravesically implanted into the bladder to record the IVP. Three days later, the awake cystometry was performed, and PGE2 was given intravesically to induce detrusor overactivity (DO). With the conventional pressure and volume parameters, the new parameter of flow pressure was investigated. Results: Recorded as the flow pressure, male rats exhibited higher urethral resistance than female rats in normal state. After DO induced, male rats showed higher urethral resistance than those of control cycles. However, female rats did not show the increased urethral resistance after DO induced (Fig. 1). Conclusions: An increase in urethral resistance through the outlet region was induced in male rats after intravesical PGE2 instillation, but not in female rats. This result indicates that overactive bladder has different mechanisms and responses in different sex.