Characteristics of vascular properties using pulse wave analysis in patients diagnosed with vasovagal syncope

초록

Title : Characteristics of vascular properties using pulse wave analysis in patients diagnosed with vasovagal syncope Ji-Hun Jang1, Kyu-yong Ko1, Yong-Soo Beak1, Sung-Woo Kwon1, Sung-Hee Shin1, Sang-Don Park1, Seong-Ill Woo1, Jun Kwan1, Dae-Hyeok Kim1 Backgrounds : Vasovagal syncope(VVS) is common cause of recurrent syncope. But the exact hemodynamic mechanism has not been elucidated. The pulse wave analysis(PWA) is widely used to evaluate vascular property which reflects the condition of the entire arterial system. Aims : To investigate the association between findings of pulse wave analysis(PWA) in VVS patients. Methods : We investigated consecutive patients who suspected VVS and performed head-up tilt test(HUT) and PWA from June 2014 to July 2016. The criteria of the heart rate-corrected augmentation index(AIx@75) and pulse-wave velocity(PWV) was estimated as a composite marker of wave reflections and arterial stiffness. Results : A total 72 patients were enrolled (VVS=51, mean age=39.1±2.0, female=46(64%)). Compared to the subjects with negative HUT group, the VVS patients had the higher AIx@75 value than negative HUT group(18.3±12.5 vs. 11.2±14.3, P=0.04). In subgroup analysis, AIx@75 showed significantly higher in VVS than negative HUT and tends to be more higher in young VVS patients(P<0.001). Conclusion: This study suggest that VVS patients were increased arterial stiffness and especially young VVS patients tend to further increased AIx@75 .