한국인유전체역학조사사업 자료를 활용한 대사증후군 관련 대사체 연구 동향: 스코핑 리뷰

초록

This study explored the research trends on metabolites associated with metabolic syndrome in Koreans using data from the Korean Genome and Epidemiology Study (KoGES). A scoping review methodology was employed to analyze articles published between 2016 and 2024 that utilized the KoGES dataset. Relevant articles were identified through the RISS, KISS, DBpia, PubMed, and Google Scholar databases. A total of 9 articles were selected, focusing on the associations between various metabolites and metabolic syndrome components. Among the selected articles, amino acidrelated metabolites were addressed in 7 articles, lipid-related metabolites such as phosphatidylcholines in 7 articles, sphingomyelin metabolites in 3 articles, carbohydrate metabolites like hexose in 3 articles, and biogenic amines such as spermine in 2 articles. Amino acids, particularly branched-chain amino acids (BCAAs), were positively associated with type 2 diabetes risk, while glycine and arginine bioavailability showed protective effects. Lipid-related metabolites, such as lysophosphatidylcholines and sphingomyelins, were linked to both metabolic syndrome and its components, including hypertension and postprandial glucose. Hexose, a carbohydrate metabolite, was associated with increased insulin resistance and impaired pancreatic β-cell function, contributing to elevated postprandial glucose levels. Biogenic amines, particularly spermine, were negatively related to type 2 diabetes risk. This scoping review highlights the importance of metabolomics in the early diagnosis and personalized management of metabolic syndrome, demonstrating the value of large-scale data like KoGES in developing tailored health strategies for diverse populations.

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