New potent and selective ligands for Dopamine receptors, aryl piperazyl 1,2,3-triazole derivertives

초록

1,2,3-Triazoles are well known heterocyclic structure as the key pharmacophore in medicinal chemistry. In continuation of our research for the discovery of potent ligands against dopamine receptor, the new ligands of substituted aryl piperazyl 1,2,3-triazole library is designed and synthesized by using of microwave synthesizer efficiently. Their binding affinities of constructed compounds were evaluated against dopamine receptors in vitro. And also, their structure-activity relationship will be discussed.