Prognostic predictors for Radioresponsiveness in Primary Non-Small Cell Lung Carcinomas

초록

Apoptosis and proliferative activity can contribute to the formation of cancer as well as influence tumor response to chemotherapy and radiotherapy. p53 protein and Bcl-2 family are important regulators of apoptosis. The aim of this study was to investigate the expression of p53 protein, Bcl-2 protein. Apoptotic index and Ki-67 labelling index in 44 archival bronchoscopic biopsy specimen obtained from patients prior to radiotherapy and its relation to the radioresponsiveness. Ten patients of them were treated combined chemotherapy. 33 squamous cell carcnomas, 9 adenocarcinomas, one adenosquamous carcinoma and one large cell undifferentiated carcinoma were included in the study. We classified these tumors into two groups according the responsiveness to the radiotherapy. Responder group included the cases showing complete remission or partial remission. p53 expression was detected in 68.2% and 26.7% of responder and nonresponder group. Bcl-2 expression was detected in 27.3% and 26.7% of responder and nonresponder group. The mean Apoptotic index was 11.7 and 12.0 in responder and nonresponder group. The mean Ki-67 labelling index was 22.2 and 20.1 in responder and nonresponder group. There was no statistically significant correlation between the radioresponsiveness and expression of Bcl-2 protein, apoptotic index and Ki-67 labelling index. But p53 protein expression could predict the radiosensitivity of the non-small cell lung carcinomas (p=0.0131).