Fibroblast Growth Factor 23 and Bone Mineral Density in Normal and Patients with End Stage Renal Disease

초록

Introduction: In addition to parathyroid hormone and vitamin D, phosphate-regulating factor, phophatonins have been shown to be associated with the hypophosphatemic rickets and autosomal dominant hypophosphatmic rickets(ADHR). Fibroblast growth factor 23, circulating phosphaturic factor increased in ADHR, tumor induced osteomalacia(TIO) and end stage renal disease(ESRD). However, the role of FGF23 in pathologic condition is not yet clear. We investigated association of FGF23 and phosphate regulation in patients with ESRD. Conclusion: These findings suggest that FGF23 and serum phosphorus are independently regulated and have little role in bone metabolism in patients with ESRD. Disclosures: S.B.Hong, None.