Prognostic Predictors for Radioresponsiveness in primary non-small cell lung carcinomas

초록

Apotosis and proliferative activity can contribute to the formation of cancer as well as influence tumor response to chemotherapy and radiotherapy. p53 protein and Bcl-2 family are important regulators of apoptosis. the aim of this study was to investigate the expression of p53 protein, Bcl-2 protein, apoptotic index and Ki-67 labelling index in 44 achival bronchoscopic biopsy specimen obtained from patients prior to radiotherpy and its relation to the radioresponsiveness. Ten patients of them were treated combined chemotherpy. 33 squamous cell carcinomas, 9 adenocarcinomas, one adenosquamous carcinoma and one large cell undifferentiated carcinoma were included in this study. We classsified these tumors into two groups according the responsiveness to radiatherapy. Responder group included the cases showing CR or PR. p53 expression was detected in 68.2%, 26.7% of responder and nonresponder group. Bcl-2 expression was detected in 27.3% and 26.7% and nonresponder group of responder and non-responder group. The mean apoptotic index was 11.7+/- 6.2 and 12.0+/-8.0 in responder and nonresponder group. The mean Ki-67 labelling index was 22.2+/-16.8 and 20.1+/-16.3 in responder and nonresponder group. There was no statistically significant correlation between the radioresponsiveness and expression of Bcl-2 protein, apoptotic index, and Ki-67 labelling index. But p53 protein expression could predict the radiosensitivity of the non-small cell lung carcinomas(p=0.0131)