Synthetic studies and their biological activities of regioselective aryl 1,2,3-triazole derivatives for dopamine receptors

초록

Functionalized five-membered heterocyclic with two or three heteroatoms, such as imidazoles, thiazoles, triazoles and others, are key structural units in many pharmaceutical preparations. Among them, 1,2,3-triazole derivatives are useful molecules which exhibit a wide range of biological activities and appear as key structural units in many important pharmaceuticals. 1,2,3-triazole structure is one of key scaffolds and building blocks in the construction of complicated organic compounds. Though our previous studies on the discovery of potent and selective ligands against dopamine receptor, 1,2,3-triazole library having mixed two regio isomers is designed and synthesized by click chemistry. These constructed libraries have potent binding affinities mixed two regio isomers. In this study, the synthetic pathway for regioselective isomers by using of metal catalyzed click chemistry has been studied, and also, it will be discussed their binding affinities.