Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Nadagouda, Mallikarjuna N.; Vijayasarathy, Pooja; Sin, Aebin; Nam, Heeyeon; Khan, Sanaullah; Parambath, Javad B. M.; Mohamed, Ahmed A.; Han, Changseok

doi:10.1007/s00044-022-02924-9

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Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

Nadagouda, Mallikarjuna N.;
Vijayasarathy, Pooja;
Sin, Aebin;
Nam, Heeyeon;
Khan, Sanaullah;
... Han, Changseok;
외 2명

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109

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120

초록

Compounds with antimicrobial activity have gained much attention in research due to the outbreak of coronavirus disease 2019 (COVID-19). Quaternary ammonium salts (QASs) are an emerging group of antibacterial agents that are used as disinfectants. Many studies have been carried out involving the applications of QASs as antifouling agents for the inhibition of biofilm growth on medical implants and antibacterials on surfaces and in an aquatic environment. In investigating the antibacterial activity of QASs, we addressed the structure-activity relationship and the physicochemical factors. This review is focused on the fine-tuning of the chemical structures of QASs for their applications as wide antibacterial agents. [GRAPHICS] .

키워드

Antibacterial activities; Disinfectants; Quaternary ammonium salts; Biofilms; ANTIBACTERIAL ACTIVITY; IN-VITRO; L-PHENYLALANINE; BONDING AGENTS; AMPHIPHILES; SURFACE; CYTOTOXICITY; RESISTANCE; MECHANISM; BIS

제목: Antimicrobial activity of quaternary ammonium salts: structure-activity relationship

저자: Nadagouda, Mallikarjuna N.; Vijayasarathy, Pooja; Sin, Aebin; Nam, Heeyeon; Khan, Sanaullah; Parambath, Javad B. M.; Mohamed, Ahmed A.; Han, Changseok

DOI: 10.1007/s00044-022-02924-9

발행일: 2022-10

유형: Review

저널명: Medicinal Chemistry Research

권: 31

호: 10

페이지: 1663 ~ 1678