Imaging prostatitis with Tc-99m Ciprofloxacin

초록

Aim: Tc-99m ciprofloxacin (Infecton) imaging was developed to discriminate infection from inflammation. It claims to show an area of viable, proliferating bacterial population that is actively using DNA gyrase, which the ciprofloxacin inhibits. We investigated the diagnostic value of the Tc-99m ciprofloxacin imaging for CBP by comparing the results of the imaging with those from the conventional tests. Materials and methods: We custom-formulated a Tc-99m ciprofloxacin kit. We used stannous tartrate for a reducing agent in making the kit. SPECT images of the region of interest were obtained at 3 hours after injection of the radiopharmaceutical. For positive control, we imaged 2 patients: acute prostatitis and urethritis. Then the actural study included 20 subjects. Results: By conventional tests, there were 10 subjects with CBP and 10 normal subjects. The typical pattern in the Tc-99m ciprofloxacin imaging indicating CBP was increased uptake around the prostatic urethra. Five of the 10 subjects with CBP diagnosed by conventional test showed the increased uptake to be positive areas in the Tc-99m ciprofloxacin imaging. Of the 10 subjects diagnosed as normal by the conventional test, 9 showed no increased uptake. Conclusions: The Tc-99m ciprofloxacin imaging and the conventional tests for diagnosing CBP show fair to good agreement. We suggest that the Tc-99m ciprofloxacin imaging will be a useful diagnostic method and will contribute to localizing the infection.