Mimicking Anatomical Arrangement, Geometry, Materials Properties, and Dynamic Nature of Tissues and Their Applications

초록

Mimicking Anatomical Arrangement, Geometry, Materials Properties , and Dynamic Nature of Tissues and Their Applications Soonjo Kwon1* and Timothy Doyle2 1인하대학교 공과대학 생명공학과, 2Department of Physics, Utah State University 전화010-8266-1238, FAX(032)872-4046, e-mail:soonjo.kwon@inha.ac.kr All cells or tissues are exposed to specific microenvironments that are generated locally at the micro- or nano-scale level by cell–cell, cell-soluble factor, or cell–extracellular matrix interactions which influences cell functions in their tissues. For the closer approximation of the function of specific tissues, we need to mimic not only anatomical arrangement of specific types of tissues, but also dynamic nature of the tissues. In addition, recent effort have been made on the hierarchical branching structures of airways and vasculature. Several cases will be introduced in this presentation. Each cell type is specifically tuned to the specific microenvironments in which it resides. Discovery of new materials, modification of materials properties, and generation of mechanical stress fields in tissue engineered micro-device enable us to finely tune a normal or pathophysiological state of specific tissue. In this presentation, several examples for these attempts will also be introduced.