Gingko Biloba could Improve the Migraine in the Patients with Right-to-Left Shunt.

초록

Objectives: To determine the efficiency of Gingko Biloba in the migrainers with right to left shunt(RLS)Background: Right-to-left shunt (RLS) is known to be associated with classical migraine maybe due to paradoxical embolism or chemical effect to brain. However, it has not been studied, whether the gingko biloba can improve the migraine in the patients with RLS. Methods: We performed a retrospective review of the medical records of the migrainers with medication of gingko biloba , who visited our hospital for treatment of migraine from January, 2008 to July, 2013 and who took the agitated saline test, using Transcranial Doppler sonography for the detection of RLS, defined as ≥11 microembolic signals(MESs). We analyzed the association between the existence of RLS and the change of numeric rating scale of headache before and after medication of ginko biloba. Results: A total of 124 patients were included in this study. Among 43 patients with RLS, 38(88.2%) patients showed the decrease of NRS. Among 81 patients without RLS, 45(55.6%) subjects showed the decrease of NRS. The medication other than ginkgo biloba was not different between the participants with RLS or the ones without. On multivariate binary regression test, the existence of RLS and the old age were significantly associated with headache improvement in the migrainers with the medication of gingko biloba. Conclusion: The gingko biloba wasa associated with the headache improvement in the migrainers with RLS. These results suggest that migraine in the patients with RLS could be controlled with the improvement of cerebral blood flow.