Clinical manifestation and survival outcomes according to body mass index inhepatocellular carcinoma patients; an analysis of a nationwide cancer registrydatabase

초록

Background and Aims : Body mass index (BMI) is a value derived from the weight and height of individual, and is known to be closely related to the prognosis and mortality of various disease. The aims of our study is to evaluated the differences of post-treatment overall survival (OS) according to BMI in the patients with hepatocellular carcinoma (HCC), and to determine the meaning of BMI in these patients. Materials and methods: The archived records of 10,578 HCC patients registered at the Korean Central Cancer Registry from 2008 through 2014 were retrospectively analyzed. In this registry, we selected Barcelona Clinic Liver Cancer (BCLC) 0, A, or B staged HCC patients (n=4,977). We compared normal weight (BMI 18.5-24.9 kg/m2, n=1,790) and overweight (BMI 25-29.9 kg/m2, n=1,790) patients after propensity score matching (PSM), and analysed the difference of OSs of these patients according to the treatment method. Results: Among a total of 4,977 HCC patients, 151(3.0%), 3,014 (60.6%), 1,607 (32.3%), and 205 (4.1%) patients had BMI of underweight, normal, overweight, and obesity, respectively. HCC patients showed good prognosis in the order of overweight, normal, obesity, and underweight. However, comparing normal and overweight in HCC patients after PSM, there was no significant difference in survival rate between two groups(p=0.153). In separate analyses of males and females, the overweight had better prognosis than the normal body weight in male (p=0.014), but there was no significant difference in the OS between two groups in females (p=0.156). Overweight patients showed better OS in Transarterial Chemoembolization (TACE) treatment (p=0.039) compared to normal body weight, but not in surgical resection(p=0.618), radiofrequency ablation(p=0.553), or sorafenib(p=0.241). Conclusions: In patients with HCC of BCLC 0-B, overweight patients showed good prognosis, but there was no significant difference between overweight and normal body weight after PSM.