Bioinformatic analysis of protein phosphatase complement of zebrafish genome

초록

Reversible protein phosphorylation is one of the major post-translational modifications of proteins which is crucial for the activation and functional regulation of the proteins. Approximately 30% of cellular proteins have been shown to contain covalently bound phosphate. Protein kinases and protein phosphatases which respectively add and remove phosphate group of target proteins, constitute about 2-4% of the genes in a typical eukaryotic genome. Protein phosphatases are amongst the extensively studied proteins and are reported as potential drug targets of many diseases including cancer and others. Here, we studied in silico identification, classification and analysis of protein phosphatases found in zebrafish genome. We found at least 185 putative protein phosphatases in zebrafish genome which include 117 PTPs, 53 PSTPs, and 15 Asp-based protein phosphatases.