신생아 중환자실 사용 약물의 비호환성 정보로 구성하는 이차원 표 개발

초록

Background : The majority of drugs used in the Neonatal Intensive Care Unit (NICU) are unlicensed and off-label, exposing infants to greater risk of medication error in the intravenous drug co-administration process. Methods : A cross-sectional analytical study was conducted in the NICU of a university hospital in Korea. Data on prescribed orders May-July 2019 were collected. Medications including intramuscular injection instruction were excluded. Prescription orders were classified in percentages according to WHO-ATC (anatomical therapeutic chemical). When two drugs were administered at the Y site at the same time, the compatibility information was investigated using the Micromedex and then classified in percentages for each drug group. A two-dimensional table with the 43 intravenous drugs prescribed was rendered based on a review of the Micromedex database. Results : The largest drug distribution in the Neonatal Intensive Care Unit (NICU) is anti-infective for systemic use (37.2%), and the drug group with the highest incompatibility comprising the nervous system drugs (28.1%). The prescription of Phenytoin, Ampicillin sodium, and Furosemide with high incompatibility were risk factors for potential incompatibility. Conclusion : It is expected potential drug incompatibility is common in the NICU. Clinical pharmacists thus must practice special monitoring when drugs are co-administered. The two-dimensional table can be a valuable tool for intervention. More research is needed to understand the actual drug incompatibilities and their clinical outcomes.

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