Serum chemerin levels are positively correlated with abdominal visceral fat in type 2 diabetes

초록

Chemerin is a recently identifi ed adipokine suggested to play a role in obesity and its metabolic complications. Although a positive correlation between visceral fat accumulation and serum chemerin levels in non-diabetic subjects has been shown, the relationship in type 2 diabetic subjects is unknown and may differ with non-diabetic subjects. We evaluated whether serum chemerin was associated with visceral abdominal fat accumulation in type 2 diabetic patients. A total of 218 Korean type 2 diabetic patients were enrolled. Abdominal visceral and subcutaneous fat areas were measured by computed tomography and serum chemerin levels were measured by ELISA. Multiple regression analysis showed that abdominal visceral fat area, serum triglyceride, creatinine clearance, hs-CRP and fi brinogen independently affected serum chemerin levels. The serum chemerin was probably predictors of visceral adiposity and may play an important role in infl ammation, diabetic nephropathy and cardiovascular disease that cause mortality in type 2 diabetes. Clinical utility of chemerin as a biomarker of metabolic syndrome in type 2 diabetes could be useful in early detection of these pathological states.