Lead induces phosphorylation and destabilization of neuronal nitric oxide synthase via VIA CaMK II-dependent mechanisms in the aged SH-SY5Y dopaminergic cells.

초록

Lead(pb+2) has been known as a neurotoxic agent that can induce defective neurodevelopment. A neurotransmitter nitric oxide(NO) release in the brain has been frequently modified under lead esposure. However, the related mechanisms were not established. In the study , we examined the effects of Pb2+ exposure on the expression and modification of neuronal NO synthase(nNOS) and the mediated pathways contribute to NO release. (중략) Our results suggest that lead-induced neuronal toxicity implies the severe decrease of the NO release in the aged SH-SY5Y cells, and is caused synergistically by CaMK II-dependent mechanisms of Nnos phosphorylation and destabilization.