Kinetics and mechanism of the benzylaminolysis of alpha-chloroacetanilide in DMSO.

초록

The nuceophilic substitution reactions of substituted alpha-Chloroacetanilide with substituted benzylamines have been studied kinetically in DMSO solvent. The transition state (TS) structure and their variations for the reactions are disscused. The kinetic results show that the studies reactions proceed by the associative SN2 mechanism ; px=-0.63~-0.43, bx=0.56~0.81, and px=0.43~0.56 values show that bond formation is greater than bond breaking in the transition state.