Cooper chelation chemistry with various chelators for radiopharmaceuticals

초록

Over a few decades, copper radioisotopes and their chelation chemistry for radiopharmaceuticals haveplayed crucial role in the radiopharmaceutical science area. A variety of chelators have been required fortheir stable targeting ability in physiological conditions. For radiolabeling with copper-64 into biomolecules,thermodynamic stability, kinetic inertness, pH stability, and redox stability should be considered. In this regard,many researchers have attempted to develop the chelators that can bind with copper more tightly, rapidlyand stably for copper radiolabeling. This review discusses the chemistry of copper, its suitable chelators andcharacteristics, while elucidating the evaluations of each chelator for radiolabeling.

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