Proton MR Spectroscopy를 이용하여 재발성 직장암과 섬유화의 비교연구

초록

PURPOSE: To know the differences of proton MR spectroscopic features between recurrent rectal cancer and fibrosis in post-operative period, and to evaluate the possibility to discriminate recurrent rectal cancer from post-operative fibrosis by analysis of proton MR spectra. MATERIALS AND METHODS: We evaluated the proton MR spectra from 25 soft tissue masses in perirectal area that developed in post-operative period for the resection of rectal cancer. Our series included 11cases of recurrent rectal cancer and 14 of fibrotic mass. Sixteen men and nine women were included in our series. All cases of recurrent rectal cancer and post-operative fibrosis were confirmed by biopsy. Parameters using in MRS were: TR=over 3000 ms, TE=30 ms, number of scans=128, voxel size=3.4(1.5 1.5 1.5)cm , and onNEX. The ratio pf peak area of all peaks at 1.6-4.1 ppm to lipid (0.9-1.6 ppm) P(1.6-4.1ppm)/P(0.9-1.6ppm)was calculated in recurrent rectal cancer and post-operative fibrosis groups. RESULTS: Proton MR spectra of post-operative fibrosis showed significantly diminished amount of lipids compared with that of recurrent rectal cancer. The ratio of P (1.6-4.1 ppm)/P (0.9-1.6 ppm) in post-operative fibrosis was much higher than that of recurrent rectal cancer with statistical significance (p .05) due to decreased peak area of lipids. Mean standard deviations of P (1.6-4.1 ppm)/P (0.9-1.6 ppm) in post-operative fibrosis and recurrent rectal cancer group were 2.71 1.48 and 0.29 0.11, respectively. With a cut-off value of 0.6 for discriminating recurrent rectal cancer from post-operative fibrosis, both the sensitively and specificity were 100% (11/11, and 14/14). CONCLUSION; Recurrent rectal cancer and post-operative fibrosis can be distinguished from each other by analysis of proton MR spectroscopic features and H-MRS can be a new method for differential diagnosis between recurrent rectal cancer and post-operative fibrosis.