Establishment of penile fibrosis model using mouse NIH3T3 fibroblasts expressing transforming groe\wth factor-B1

초록

TGF-b1 has been suggested to be an important cytokine to induce cavernous fibrosis, which inevitably results in erectile dysfeunction(ED). This study was indertaken to establish chroinc rat model with cavernous fibrosis using mouse NIH3T3 fibroblasts, which express TGF-b. NIN3T3-TGF b1 cell sufficiently induced relatively long lasting cavernous fibrosis. This model may contribute to further investigation of the pathogenesis of penile fibrosis associated with TGFb1 signal and devepoment of new therapeutics targeting this signal transduction.