Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure-Activity Relationships for Vitiligo

Song, Jae-Won; Choi, Sunju; Kim, Gayeong; Lee, Hyang Bok; Rao, P. Sankara; Shin, Jeonghyun; Kim, Eun Ki; Cho, Dong-Gyu

doi:10.3390/molecules27072135

상세 보기

Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure-Activity Relationships for Vitiligo

Song, Jae-Won;
Choi, Sunju;
Kim, Gayeong;
Lee, Hyang Bok;
Rao, P. Sankara;
... Shin, Jeonghyun;
... Cho, Dong-Gyu;
외 1명

Citations

WEB OF SCIENCE

3

Citations

SCOPUS

3

초록

A novel melanoblast stimulator (1) was isolated from Dimocarpus longan. Its analogs were also synthesized to support a new furan-based melanoblast stimulator scaffold for treating vitiligo. Isolated 5-(hydroxymethyl)furfural (HMF, 1) is a well-known compound in the food industry. Surprisingly, the melanogenic activity of HMF (1) was discovered here for the first time. Both HMF and its synthetic analog (16) promote the differentiation and migration of melanoblasts in vitro. Typically, stimulator (1) upregulated MMP2 expression, which promoted the migration of melanoblasts in vitro.

키워드

melanoblast; stimulator; melanogenesis; vitiligo structure-activity relationships; MELANOCYTE STEM-CELLS; BIOLOGICAL EVALUATION; MELANIN SYNTHESIS; B16 CELLS; REPIGMENTATION; DERIVATIVES; MIGRATION; HAIR; PUVA

제목: Isolation of a Melanoblast Stimulator from Dimocarpus longan, Its Structural Modification, and Structure-Activity Relationships for Vitiligo

저자: Song, Jae-Won; Choi, Sunju; Kim, Gayeong; Lee, Hyang Bok; Rao, P. Sankara; Shin, Jeonghyun; Kim, Eun Ki; Cho, Dong-Gyu

DOI: 10.3390/molecules27072135

발행일: 2022-04

유형: Article

저널명: Molecules

권: 27

호: 7