Merkel cell carcinoma의 압착도말 세포학적 소견 -1예 보고-

초록

Merkel cell carcinoma (MCC) is a rare and locally aggressive cutaneous neuroendocrine carcinoma that usually arises in the head and neck or the extremities elderly patients. We describe the cytologic features of touch imprint of MCC. The patient was a 52 year-old female who presented with a facial mass. The touch imprint was obtained from an incision biopsy specimen that was submitted for frozen section. The touch preparation produced highly cellular imprint of loosely cohesive clusters and individual malignant tumor cells. Characteristic features of the tumor cells including round to oval with monomorphic nuclei, fine chromatin, inconspicuous nucleoli, and numerous mitosis raised differential diagnosis of malignant small round cell tumors. We had an opportunity to apply cytokeratin and cytokeratin 20 for immunocytochemistry to the touch imprint, demonstrating the tumor cells with the paranuclear dot-like positivity.