Antiobesity and hypolipidemic effects of taurine-ribose supplementation in rats fed a high-fat diet

초록

Taurine-ribose(T-rib) was newly synthesized compound with taurine and ribose. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of T-rib supplementation in rats fed a high-fat diet. Four week-old male Sprague-Dawley rats were randomly divided into seven groups with 8 rats in each group for a period of 6 weeks (normal diet, N group; high-fat diet, HF group; high-fat diet+taurine(4 mmol/kg/day), HFT group; high-fat diet+β-alanine, HFA group; high-fat diet+β-alanine+ T-rib(2 mmol/kg/day), HFR2 group; high-fat diet+β-alanine+ T-rib(4 mmol/kg/day), HFR4 group; high-fat diet+β-alanine+ T-rib(6 mmol/kg/day), HFR6 group). Taurine and T-rib were orally administrated to the HFT and HFR groups. The same amount of distilled water was orally administered to the other groups daily. β-Alanine was supplemented to induce taurine deficiency by dissolving in feed water(3% w/w). Body weight gain, relative adipose tissue weights, and size of adipocytes were measured as markers for antiobesity effect, and serum total, HDL, and LDL cholesterol and triglyceride levels were analyzed as markers for hypolipidemic effect. T-rib supplementation significantly suppressed body weight gain and relative adipose tissue weights in rats fed a high-fat diet. Also average sizes of adipocytes in HFR groups were smaller than those of the HF and HFA groups. Concentrations of total and HDL cholesterol in the HFT and HFR groups were significantly improved compared to the HF and HFA groups. These results suggest that the T-rib have antiobesity and hypolipidemic effects in rats fed a high-fat diet.