Design and Synthesis of 5-Arylidene-2-arylimino-4-thiazolidinone as PTP1B inhibitors

초록

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type 2 diabetes and pbesity: however, targeting PTP1B for drug discovery is challenging because of the highly conserved and positivelr charged active-site pocket.