Lewis Acid Promoted Asymmetric Diels-Alder Reaction of Tropane and (R)-3-Hydroxypiperidine Derivatives

초록

Tropane and (R)-3-hyroxypiperidine derivatives were prepared as an efficient auxiliary group for asymmetric Diels-Alder reeaction. Those Diels-Alder cycloadditions proceeded with high diastereofacial selectivity and enantiomeric exess, giving either endo-R or endo-S products depending on Lewis acid and the structure of dienophile.