Anticoagulatory effect of an earthworm, Lumbricus lubellus, was due to deoxyribonucleic acid

초록

An earthworm known for its anti-inflammatory, analgesic, antipyretic, and anticancer effects has been recognized for its facilitatory effect on blood circulation as a folk remedy. After complete heat inactivation of endogenous proteases in an earthworm, L. rubellus, an anticoagulant was purified to 2,800-fold through ammonium sulfate fractionation, gel permeation chromatography, and C4 reversed-phase HPLC.